Artile investigation of the protective effect of kefir. Isoproterenolinduced myocardial infarction in rats. Acute treatment with metformin improves cardiac function. Cardioprotective effect of squalene on lipid profile in. Pdf origination and development of isoproterenolinduced. Adult male and female spraguedawley rats were subjected to an isopro terenol induced myocardial infarction. Jan 11, 2020 our study is aimed at evaluating the effects of pretreatment with polylactic. Experimental model of myocardial infarction induced by. Isoproterenolinduced myocardial infarction in rabbits. Cardioprotective effect of ritonavir, an antiviral drug, in. Luteolin7diglucuronide attenuates isoproterenolinduced. The inflammatory responses play a major role in the pathogenesis of acute myocardial infarction mi.
Male wistar rats were orally given ginsenoside re 5, 20 mgkg daily for 7 days. The effect of astragaloside iv on isoproterenol induced myocardial infarction in rats article pdf available in pharmaceutical sciences 252. All national and international guidelines for the care and use of animals were closely followed. A biochemical, electrocardiographic and histoarchitectural evaluation. Ginsenoside re attenuates isoproterenolinduced myocardial. Two hundred mgkg iso dose was selected for the present study as this dose offered significant.
Mature male rats with isoproterenol induced myocardial infarction and normal controls were injected intravenously with 1, 23 h corticosterone 3 h corticosterone. Curcumin from curcuma longa is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress induced damage. Jan 23, 2017 the animal model of iso induced myocardial injury recapitulates major metabolic and morphological changes that occur during human myocardial infarction, thus being widely adopted as an. The rats were subcutaneously injected with isoproterenol iso 85 mgkg at an interval of 24 hours for two days. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles ccnp compared to conventional curcumin cc on isoproterenol iso induced myocardial infarction mi in rats. Diabetes and isoproterenol induced myocardial infarction was evident as a reduction in maximal positive and negative rate of developed left ventricular pressure and an increase in left ventricular enddiastolic pressure. Myocardial infarction induced by isoproterenol iso using toxic concentration of this.
Pdf evaluation of cardioprotective role of vinpocetine. Apoptosis, inflammation, isoprenaline, myocardial infarction. Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats. Cardioprotective effects of puerarinv on isoproterenol. Nov 23, 2017 sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats. Alprazolam decreases isoproterenol induced myocardial damage. Cardio protective role of wogonin loaded nanoparticle against.
However, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear. Isoproterenol iso administration induced the myocardial injury as evidenced by. Polyphenol was extracted from cocoa using a hydroalcohol solvent. In addition to its antiviral effect, ritonavir directly inhibits the insulinregulated glucose transporter glut4 and blocks glucose entry into fat and muscle cells. The protective effect of scu on isoinduced mi was evaluated by measuring markers of.
Isoproterenol injections alone caused the expected cardiotoxicity. Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1, 23h corticosterone 3h corticosterone. Effect of gonadectomy on isoproterenolinduced myocardial. Myocardial infarction induced by isoproterenol iso. Thirty young, male, wistar rats 145 to 230 g were randomly allocated in two groups. Therefore, mi in animal models studies should be induced in conscious animals with intact reflexes for greater clinical re levance. This study aimed to investigate the protective effect of betaine on tissue structure and renal function after isoprenaline. Possible effect of natural honey on isoproterenol induced acute myocardial infarction in adult male albino rats marwa a omar, fatma elnabawia, a elsafty, wael b elkholy and abeer e elmehi department anatomy and embryology, faculty of medicine, menoufia university, menoufia, egypt submission. Myocardial infarction, lipid peroxidation, black cumin, cardiac markers myocardial infarction mi is a therapeutic. In the present study, we evaluated the role of ritonavir in isoproterenol induced. Lipid peroxidation and antioxidants as biomarkers of tissue damage. The present study is undertaken to evaluate the effect of esculetin on the levels of lipid peroxidation and antioxidants in isoproterenol iso induced myocardial infarction mi in wistar rats.
Original article baicalin ameliorates isoproterenolinduced. Fiftysix wistarbratislava white rats were randomly divided into eight groups of seven rats each. Vinpocetine is a phosphodiesterase type1 inhibitor having strong vasodilating effect through camp and cgmp elevation. Shift in antioxidant parameters, lactate dehydrogenase ldh together with morphological and histopathological changes were investigated.
In this research, we aim to evaluate the cardioprotective effects of puerarinv on the isoproterenol iso induced mi mice and elucidate the underlying mechanisms. Origination and development of isoproterenolinduced myocardial infarction in male wistar rats. The present study was designed to investigate the cardioprotective effects of sundarban honey sh in rats with isoproterenol iso induced myocardial infarction. Protective effect of taurine on myocardial antioxidant status. Europium hydroxide nanorods ehns ameliorate isoproterenol. Rats were randomly assigned to exercise and control groups. Wogonin, one of the main active ingredients of scutellaria radix, is a kind of flavonoid compound. Henceforth, in the present study, myocardial ischemia mi was created in wistar rats using isoproterenol iso, a wellestablished model for investigating mi. Dec 14, 2018 however, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear. Sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats. Further, these proangiogenic nanorods were also reported to exhibit a mild to nontoxic nature toward mammalian cells and mouse models. Preventive effect of agnucastoside c against isoproterenolinduced. Curcumin nanoparticles protect against isoproterenol induced. Six weeks before the induction of myo cardial infarction, some of the animals had been orchiectomized or ovari ectomized.
Protective effects of cardamom in isoproterenolinduced myocardial. Trakya university institute of health sciences, master thesis in department of medical biochemistry, edirne, turkey. Myocardial trauma and damage were induced by two doses of isoproterenol 40 mgkg. For this,tamoxifen was administered to spraguedawley rats for 114 days, and isoproterenol iso 100 mgkg body mass. Blood and tissue samples liver, brain, adrenal glands, normal and necrotic areas of the heart were collected 15, 30, and 45 minutes after tracer injection. This study aimed to investigate the protective effect of ginsenoside re on isoproterenol induced myocardial injury in rats. The protective impact of betaine on the tissue structure and. Original article baicalin ameliorates isoproterenol induced acute myocardial infarction through inos, inflammation, oxidative stress and p38mapk pathway in rat shenjie sun, xiaopeng wu, hengliang song, guiqi li department of cardiology, the second hospital affiliated to zhengzhou university, zhengzhou 450014, henan, china. Exercise training, indomethacin, and isoproterenolinduced.
Based on the results presented, we conclude that the model of myocardial infarction induced by isoproterenol in rats was adequately reproduced and validated in our laboratory and caused increased mortality and myocardial injury markers ast and troponin i, reduction of catalase activity and levels of glutathione and histopathological changes. The animals were autopsied at regularly timed intervals on days 1, 2, 3, 8, and 15 after myocardial infarction. Fifty wistar strain male albino rats, weighing 200 10, were selected for the study. A tool for inducing myocardial infarction in experimental animals, authormohd aftab siddiqui and usama sharif ahmad and ahmed abdullah khan and mohammad ayaz ahmad and badruddeen and mohammad khalid and juber akhtar, year2016. Myocardial infarction is usually induced in small animals by means of invasive techniques based on mechanical coronary obstruction. Myocardial damage induced by a single high dose of.
Pretreatment with black cumin offered a protective effect against isoproterenol induced myocardial infarction in rats as evidenced by cardiac markers and lipid profile of the heart tissue. The activities of creatine kinase on myocardial bundle ckmb and lactate dehydrogenase ldh were also reduced. While myocardial injury encompasses any type of acute myocardial damage such as necrosis induced by myocarditis, sepsis or endogenous catecholamines, mi is defined as ischemic damage resulting from an insufficient myocardial oxygen supply 1 2. Tacrolimus ameliorates functional disturbances and oxidative. The acute phase of myocardial necrosis induced by isoproterenol mimics changes in blood pressure, heart rate, electrocardiogram ecg, and left ventricular dysfunction similar to that occurring in patients with myocardial infarction. Forty albino rats divided into six groups of four rats each were used for the. Article pdf available in international research journal of.
Cardioprotective potential of ocimum sanctum in isoproterenol. Madhesh murugesan, ramalingam revathi, and vaiyapuri manju. The effect of pretreatment with curcumin nanoparticles nc compared to conventional curcumin cs on blood pressure, electrocardiogram, and biological changes on isoproterenol iso induced myocardial. Effects of curcumin nanoparticles in isoproterenolinduced. Mar 20, 2009 abstract the present study evaluated cardioprotective effect of lyophilized hydroalcoholic extract of moringa oleifera in the isoproterenol isp induced model of myocardial infarction. Moringa oleifera leaf extract prevents isoproterenolinduced. Mechanism of isoproterenol induced myocardial damage. The effect of astragaloside iv on isoproterenolinduced myocardial infarction in rats article pdf available in pharmaceutical sciences 252. Guidelines of our institutional animal ethical committee iaec. Pdf evaluation of cardioprotective role of vinpocetine in. It was hypothesized that endurance exercise training would attenuate isoproterenolinduced myocardial necrosis in the rat by increasing the concentration of prostacyclin in the myocardial vasculature. Preventive effect of agnucastoside c against isoproterenol.
Beneficial role of tamoxifen in isoproterenolinduced. However, the effect of ritonavir on cardiac glut4 inhibition during myocardial necrosis is not investigated. Clinical guidelines distinguish between myocardial injury and myocardial infarction mi. This model becomes relevant if we consider that increased adrenergic. Curcumin and curcumin nanoparticles were given by gavage in three di. Sixty rats were randomly divided into six groups of 10 rats each.
Preventive effect of esculetin on lipid peroxides and. Wistar male albino rats were randomly divided and treated with extract of cardamom 100 and 200 mgkg per oral or normal saline for 30 days with concomitant administration of iso 85 mgkg, subcutaneous on 29th and 30th days, at 24 h interval. Vasodilators may play positive role in myocardial infarction mi. Pdf isoproterenolinduced myocardial infarction in wistar rats. Sham group, which underwent a virtual myocardial infarction induction, and. Protective effects of cardamom in isoproterenolinduced. In the present study, we report that wogonin nanoparticles wog np protect isoproterenol iso induced myocardial infarction mi rats. The rat model of isoproterenol induced myocardial infarction offers. Myocardial infarction mi is an important cause of mortality around the world, resulting from an ischemic necrosis induced by a vascular occlusion. Ginsenoside re is the main chemical component of panax ginseng. As it has been reported that isoproterenol can cause ischemic myocardial alterations, lipid peroxide generation and procoagulant activity, we administered it to rabbits in order to induce a noninvasive myocardial infarction associated with above mentioned.
In fact, mi, an acute condition of necrosis of myocardium is the most lethal. Pdf the effect of astragaloside iv on isoproterenolinduced. Cc on isoproterenol iso induced myocardial infarction mi in rats. Pdf the effect of astragaloside iv on isoproterenol. Role of nitric oxide in isoproterenolinduced myocardial. Effect of kefir against isoproterenol induced myocardial infarction in rats 269 gutteridge jm. We have examined the protective effect of taurine on the myocardial antioxidant defense system in isoprenaline isoproterenol induced myocardial infarction in rats, an animal model of myocardial infarction in man. Protective effect of scutellarin on myocardial infarction induced by.
Possible effect of natural honey on isoproterenol induced. Myocardial infarction induction with isoproterenol raised leukocytes and neutrophils counts, sgot, troponin i and urea concentrations, reduced catalase enzyme. Jan 04, 2007 we studied the cardioprotective effect of squalene on isoprenaline induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart ti. Curcumin has antiinflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Cardioprotective effect of fenugreek on isoproterenolinduced. Introduction myocardial infarction mi is an important cause of mortality around the world, resulting. Pdf the present study was designed to investigate the cardioprotective effects of sundarban honey sh in rats with isoproterenol iso induced. Cardioprotective effect of fenugreek on isoproterenolinduced myocardial infarction in rats. Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol induced myocardial infarction arash khorrami1,2, mojtaba hammami2, mehraveh garjani2, nasrin malekidizaji1 and alireza garjani1 abstract background.